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Tourette syndrome is a neurological condition characterised by multiple recurrent involuntary tics involving body movements (such as eye blinks, grimaces, or knee bends) and vocalisations (such as grunts, snorts, or utterance of inappropriate words). Associated behaviours include attention deficit disorder and obsessive compulsive behaviours. Symptoms usually start between ages 2 and 14. Severity ranges from very mild to severe and may be disabling. The condition may be extremely variable, even within a family. Tourette syndrome affects males more often than it affects females. About 10% of people affected with Tourette syndrome have a family history of the condition. The pattern of inheritance is most likely multifactorial (a genetic susceptibility is present but an environmental trigger or triggers are also needed for the condition to occur). Tourette syndrome may be caused by a faulty copy of the SLITRK1 susceptibility gene, which is located on the long arm ‘q’ of chromosome 13 (13q31). There may be several other susceptibility genes. |